With all of the pressures on primary-care clinicians to see more patients while improving the quality of care, we need help in prioritizing the preventive services we provide. Responding to this need, the U.S. Preventive Services Task Force (USPSTF) has identified the most effective preventive measures, and a careful review has prioritized them based on how they fulfill two important criteria: burden of disease prevented when each service is delivered regularly and the cost-effectiveness of doing so (Am J Prev Med. 2006;31:52-61). This prevention priorities review of 25 USPSTF-recommended services found that only five were actually cost-effective for adults: aspirin prophylaxis for cardiovascular risk, pneumococcal immunization and vision screening for those older than 64, and tobacco-use and alcohol-misuse screening and brief counseling.